Development and Validation of a Rapid, Single-Step Reverse Transcriptase Loop-Mediated Isothermal Amplification (RT-LAMP) System Potentially to Be Used for Reliable and High-Throughput Screening of COVID-19
Detection Principle
NucleicAcid-PCR based
Target
N gene
Testing Method Category
LAMP
Testing Method
in house LAMP, SARS-CoV-2 kit from Shanghai BioGerm Medical Biotechnology Co. Ltd, DAAN Gene Co., Ltd
Reported Performance
specificity: 100% (serial dilutions), 99.5% (clinical samples) ; sensitivity: 500 copies/ml (serial dilutions), 91.4% (clinical samples) ; PPV: 97.7% ; NPV: 98.1%
Sample Size
260 patients
Peer-reviewed
yes
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