Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference
Detection Principle
NucleicAcid-PCR based
Target
ORF1, N genes
Testing Method Category
PCR_KIT
Testing Method
WHO-1 RT-PCR (Bojie Ltd, Shanghai, China)
Testing Method - Additional Info
identification of Ct cutoff values for internal reference RPP30 RT-PCR which predicted false negative results for SARS-CoV-2 RT-PCR
Reported Performance
Sensitivity: 95.03% (ORF1ab, sputum), 95.10% (N, sputum), 95.26% (ORF1ab, throat swab), 95.14% (N, throat swab) ; Specificity: 91.40% (ORF1ab, sputum), 88.16% (N, sputum), 83.72% (ORF1ab, throat swab), 98.55% (N, throat swab)
Sample Size
161 patients
Peer-reviewed
yes
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