Performance characteristics of four high-throughput immunoassays for detection of igg antibodies against sars-cov-2
Detection Principle
ImmunoAssay-Antibody
Target
IgG vs S (Euroimmun, Ortho-Clinical); IgG vs N (Epitope, Abbott)
Testing Method Category
Testing Method
kits
Testing Method - Additional Info
four high-throughput serologic tests for detection of anti-SARS-CoV-2 IgG antibodies, CMIA Abbott Laboratories (Abbott Park, IL), ELISA Epitope Diagnostics, Inc. (San Diego, CA), ELISA Euroimmun (Lubeck, Germany), and CLIA Ortho-Clinical Diagnostics (Rochester, NY)
Reported Performance
sensitivity: 92.9% (Abbott, >14dpo), 88.1% (Epitope, >14dpo), 97.6% (Euroimmun, >14dpo), 98.8% (Ortho-Clinical, >14dpo); Specificity: 99.6%(Abbott), 99.6% (Epitope), 98.0% (Euroimmun), 99.6% (Ortho-Clinical); PPV: 92.8% (Abbott), 90.6%(Epitope), 71.2% (Euroimmun), 92.5% (Ortho-Clinical)
Sample Size
224 samples
Peer-reviewed
yes
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