Evaluation of a novel multiplexed assay for determining IgG levels and functional activity to SARS-CoV-2
Detection Principle
ImmunoAssay-Antibody
Target
IgG vs S, RBD, N
Testing Method Category
Testing Method
kit
Testing Method - Additional Info
multiplexed solid-phase chemiluminescence assay (Meso Scale Discovery), Rockville, MD
Reported Performance
Specificity: 97.4 % (IgG vs S), 92.3% (IgG vs RBD), 92.8% (IgG vs N) ; sensitivity: 96.2 % (IgG vs S, 14 dpo), 91% (IgG vs RBD, 14 dpo), 84.6% (IgG vs N, 14 dpo), 97.9 % (IgG vs S, 21 dpo), 93.6% (IgG vs RBD, 21 dpo), 87.2% (IgG vs N, 21 dpo)
Sample Size
196 positive samples &194 control samples
Peer-reviewed
yes
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