Analytical and clinical performances of five immunoassays for the detection of SARS-CoV-2 antibodies in comparison with neutralization activity
Detection Principle
ImmunoAssay-Antibody
Target
IgG
Testing Method Category
Testing Method
Kits (CLIA and ELISA)
Testing Method - Additional Info
CLIA: Abbott SARS-Cov-2 IgG, Roche Elecsys anti-SARS-CoV-2, Ortho SARS-CoV-2 total and IgG; ELISA: Diesse ENZY-WELL SARS-CoV-2 IgG. Compared with the neutralization activity achieved using the plaque reduction neutralization test (PRNT)
Reported Performance
Sensitivity: from 78.5 to 87.8%( overall), 95.2 (>12 dpo, VITROassay); specificity: from 97.6 to 100% (overall).
Sample Size
184 samples (130 positive & 54 negative)
Peer-reviewed
no
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