DOI

Detection Principle

Others

Target

S protein, N protein, E protein, ORF1ab segment for PCR; IgG, IgM, IGA for serological tests

Testing Method Category

Mixed

Testing Method

39 molecular diagnostic tests: QIAstat-Dx Respiratory SARS-CoV-2 Panel (QIAGEN GmbH); NeuMoDx SARS-CoV-2 Assay (NeuMoDx Molecular, Inc.); NxTAG CoV Extended Panel Assay (Luminex Molecular Diagnostics, Inc.); ID NOW COVID-19 (Abbott Diagnostics Scarborough, Inc.); Real-Time Fluorescent RT-PCR Kit for Detecting SARS-2019-nCoV (BGI Genomics Co. Ltd); AvellinoCoV2 test (Avellino Lab USA, Inc.); PerkinElmer New Coronavirus Nucleic Acid Detection Kit (PerkinElmer, Inc.); Accula SARS-Cov-2 Test (Mesa Biotech Inc.); BioFire COVID-19 Test (BioFire Defense, LLC); Xpert Xpress SARS-CoV-2 test (Cepheid); Primerdesign Ltd COVID-19 genesig Real-Time PCR assay (Primerdesign Ltd.); ePlex SARS-CoV-2 Test (GenMark Diagnostics, Inc.); Simplexa COVID-19 Direct assay (DiaSorin Molecular LLC); Abbott RealTime SARS-CoV-2 assay (Abbott Molecular); Quest SARS-CoV-2 rRT-PCR (Quest Diagnostics Infectious Disease, Inc.); Lyra SARS-CoV-2 Assay (Quidel Corporation); COVID-19 RT-PCR Test (Laboratory Corporation of America); Panther Fusion SARS-CoV-2 (Hologic, Inc.); TaqPath COVID-19 Combo Kit (Thermo Fisher Scientific, Inc.); cobas SARS-CoV-2 (Roche Molecular Systems, Inc.); New York SARS-CoV-2 Real-time Reverse Transcriptase (RT)-PCR Diagnostic Panel (Wadsworth Center, New York State Department of Public Health's); CDC 2019-nCoV Real-Time RT-PCR Diagnostic Panel (CDC) (Centers for Disease Control and Prevention's). 18 high complexity molecular-based laboratory developed tests: UDX SARS-CoV-2 Molecular assay (Ultimate Dx Laboratory); SARS-CoV-2 Assay (AIT Laboratories); COVID-19 Key (Southwest Regional PCR Laboratory LLC. dba MicroGen DX); SARS-CoV-2 PCR Test (Diatherix Eurofins Laboratory); SARS-CoV-2 Molecular Detection Assay (Mayo Clinic Laboratories, Rochester, MN); CDI Enhanced COVID-19 Test (Hackensack University Medical Center (HUMC) Molecular Pathology Laboratory; CirrusDx SARS-CoV-2 Assay (CirrusDx Laboratories); Childrens-Altona-SARS-CoV-2 Assay (Infectious Diseases Diagnostics Laboratory (IDDL), Boston Children's Hospital); SARS-CoV-2 Assay (Exact Sciences Laboratories); SARS-CoV-2 Assay (Integrity Laboratories); COVID-19 RT-PCR Test (Pathology/Laboratory Medicine Lab of Baptist Hospital Miami); Orig3n 2019 Novel Coronavirus (COVID-19) Test (Orig3n, Inc.); ThermoFisher - Applied Biosystems TaqPath COVID-19 Combo Kit (Rutgers Clinical Genomics Laboratory-Rutgers University); SDI SARS-CoV-2 Assay (Specialty Diagnostic (SDI) Laboratories); UNC Health SARS-CoV-2 real-time RT-PCR test (University of North Carolina Medical Center); Stanford SARS-CoV-2 assay (Stanford Health Care Clinical Virology Laboratory); Viracor SARS-CoV-2 Assay (Viracor Eurofins Clinical Diagnostics); MGH COVID-19 qPCR assay (Massachusetts General Hospital); SARS-CoV-2 RT-PCR test (Infectious Disease Diagnostics Laboratory- Children's Hospital of Philadelphia); SARS-CoV-2 PCR test (Yale New Haven Hospital, Clinical Virology Laboratory). 7 serological diagnostic tests: (NCT04261426 [China];36 NCT04264858 [China];37 NCT04332380 [Colombia];38 NCT04332835 [Colombia]; 39 NCT04323800 [US, Johns Hopkins];40 NCT04325672 [US, Mayo Clinic];41 NCT04333251 [US, Baylor])

Testing Method - Additional Info

Full article available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226308/

Reported Performance

/

Sample Size

from 1 to 288 (see Table 1 for molecular diagnostic tests)

Peer-reviewed

yes