Analysis of SARS-CoV-2 Antibodies in COVID-19 Convalescent Plasma using a Coronavirus Antigen Microarray.
Detection Principle
ImmunoAssay-Antigen
Target
spike protein (S), including the receptor-binding (RBD), S1, and S2 domains and the whole protein (S1?+?S2), nucleocapsid protein (NP), and papain-like protease (PLpro)
Testing Method Category
Other Immuno assay
Testing Method
ONCYTE AVID nitrocellulose-coated slides (Grace Bio-Labs, Bend
Testing Method - Additional Info
validation of a coronavirus antigen microarray containing immunologically significant antigens from SARS-CoV-2, in addition to SARS-CoV, MERS-CoV, common human coronavirus strains, and other common respiratory viruses.
Reported Performance
IgG SARS.CoV.2.S1.mFcTag Sensitivity: 0.5629; Specificity: 0.9849; IgM SARS.CoV.2.Spike.RBD.rFc Sensitivity: 0.5894; Specificity: 0.9873; Combination of IgG and IgM sensitivity: 87.8%; Specificity: 98.9%
Sample Size
135 blood specimens
Peer-reviewed
yes
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