Improved Molecular Diagnosis of COVID-19 by the Novel Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR
Detection Principle
NucleicAcid-PCR based
Target
(RdRp)/helicase (Hel), spike (S), and nucleocapsid (N)
Testing Method Category
RT-PCR
Testing Method
in house
Testing Method - Additional Info
developed novel, highly sensitive and specific real-time RT-PCR assays for COVID-19 and compared their performances with that of the established RdRp-P2 assay using both in vitro and patient specimens
Reported Performance
LOD with in vitro viral RNA transcripts: 11.2 RNA copies/reaction; Confidence interval: 95%;?copies/reaction RNA: 7.2 to 52.6
Sample Size
273 speciemens
Peer-reviewed
yes
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