Evaluation of three fully-automated SARS-CoV-2 antibody assays
Detection Principle
ImmunoAssay-Antibody
Target
IgG and IgM
Testing Method Category
Other Immuno assay
Testing Method
SARS-CoV-2-ELISA (IgG) (Euroimmun), Elecsys anti-SARS-CoV-2 (Roche), SARS-CoV-2 Total (COV2T) (Siemens Healthineers)
Testing Method - Additional Info
comparison of ELISA, ECLIA and CLIA commercial tests
Reported Performance
Specificity: 100% ; sensitivity: 56.5% (0-6 days from+PCR, Siemens, Euroimmun), 65.2% 0-6 days after +PCR Roche), 90.3% (7-13 days after +PCR Siemens, Roche), 89.3% 7-13 days after +PCR Euroimmun), 97% (more than 14 days after +PCR Siemens), 89.4% (more than 14 days after +PCR Roche), 95.5% (more than 14 days after +PCR Euroimmun) ; remarks: using cut-off indeces some sensitivity values improve, but not specificity.
Sample Size
309 samples
Peer-reviewed
yes
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